Now recruiting for Diagnostic Project Managers (Sweden), Diagnostic Project Coordinators (Cambridge and Sweden), Diagnostic Experts (Cambridge and Sweden). See AstraZeneca careers page for opportunities.

VP and Head Personalised Healthcare & Biomarkers @ Accountable for driving Personalised Healthcare strategy; delivering companion diagnostic tests and validated biomarkers to all AstraZeneca drug projects, targeting life-changing medicines to those most likely to benefit - Leads function of 115 diagnostic experts, diagnostic & biomarker scientists, focused on companion diagnostic delivery to >20 drug projects - Drove first regulatory approval based on circulating tumour DNA, first laboratory-based companion diagnostic PMA, first novel companion diagnostic based on next-generation sequencing - Led 70% PHC adoption in AstraZeneca including examples in all therapy areas and phases of development - Demonstrated business benefits of PHC approach; new products to market, reduced clinical timelines, increased R&D success - As member of Early Stage Product Committee, evaluates “right patient” approaches for all small molecule investment decisions. - > 40 publications and patents From 2012 to Present (3 years) VP & Head, Science & Validation, Personalised Healthcare & Biomarkers @ - Leads laboratory capability delivering validated biomarkers and potential companion diagnostics to AstraZeneca's drug project teams - Delivers to >10 drug projects in clinical development on track to launch as PHC products linked to biomarkers or diagnostic tests (including Oncology, Infection, Respiratory, Cardiovascular, Neuroscience) From April 2011 to November 2012 (1 year 8 months) Interim Head, Strategy, Portfolio & Alliances, Personalised Healthcare & Biomarkers @ - Led creation of business case and corporate strategy documents - Drove Personalised Healthcare alliances strategy - Championed Personalised Healthcare-Payer dialogue - Initiated tools to facilitate AstraZeneca Personalised Healthcare portfolio review From November 2010 to April 2011 (6 months) Personalised Healthcare Leader @ - Led cross-functional team to champion and drive Personalised Healthcare approach across AstraZeneca - Delivered joint strategy including R&D, Regulatory, Commercial, Business Development - Laid groundwork for new Personalised Healthcare & Biomarkers Function From November 2007 to November 2010 (3 years 1 month) Pharmacogenetics Expert @ Senior Principal Scientist, 2004-2007 Associate Director, Head Development Genetics Group, 2001-2004 Team Leader, 1998-2001 From 1998 to 2007 (9 years) University Lecturer, Genetics @ From 1997 to 1998 (1 year) Postdoctoral Scientist @ From 1994 to 1997 (3 years)

PhD, Immunology @ University of London From 1978 to 1983 Ruth March is skilled in: Biomarkers, Clinical Development, Oncology, Genetics, R&D, Validation, Laboratory, Cross-functional Team Leadership, Strategy, Healthcare, Drug Development, Drug Discovery, Science, Lifesciences, Biotechnology