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Nicole Smits

Research Scientist

Research Scientist at The Geisel School of Medicine at Dartmouth

Greater Boston Area

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Nicole Smits's Email Addresses & Phone Numbers

Nicole Smits's Work Experience

Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth

Research Scientist

Lebanon, NH, USA

The Geisel School of Medicine at Dartmouth

Instructor in Medicine (Cardiology)

January 2012 to December 2015

Lebanon, NH

The Geisel School of Medicine at Dartmouth

Research Associate

December 2006 to December 2011

Lebanon, NH

Nicole Smits's Education

Isala College

Radboud University

Ph.D., Medical Sciences

2001 to 2006

Hogeschool van Arnhem en Nijmegen (HAN)

B.Sc., Biochemistry

1998 to 2001

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Easily bored
Casual
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21% Left Brained
79% Right Brained

Nicole Smits's Estimated Salary Range

About Nicole Smits's Current Company

Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth

Frequently Asked Questions about Nicole Smits

What company does Nicole Smits work for?

Nicole Smits works for Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth


What is Nicole Smits's role at Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth?

Nicole Smits is Research Scientist


What is Nicole Smits's personal email address?

Nicole Smits's personal email address is ni****[email protected]


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Nicole Smits's business email address is n****[email protected]


What is Nicole Smits's Phone Number?

Nicole Smits's phone (**) *** *** 327


What industry does Nicole Smits work in?

Nicole Smits works in the Research industry.


About Nicole Smits

đź“– Summary

Research Scientist @ Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth Lebanon, NH, USAInstructor in Medicine (Cardiology) @ The Geisel School of Medicine at Dartmouth Identifying the Pro-Inflammatory Mechanism in Septic ShockCurrent Funding Sources: American Heart Association (Scientist Development Grant) and SYNERGY (Scholar's Career Development Award)Role: PIThis study aims to elucidate the pro-inflammatory mechanism of HSNS4F5 in septic shock. This study focuses on in vitro and in vivo efficacy studies and will prove a comprehensive evaluation of the in vivo pro-inflammatory role of HSNS4F5 in sepsis. Focus is on optimizing, characterizing and validating anti-HS antibodies with drug-like properties to reduce the devastating impact of sepsis.During this study, I was also involved in a Phase I study with industry partner Celdara Medical, which focused on in vitro and in vivo safety studies of a mutant form of the plasma protein antithrombin. From January 2012 to December 2015 (4 years) Lebanon, NHResearch Associate @ The Geisel School of Medicine at Dartmouth 3-OST-1 Regulation of Antithrombin Isoform PartitioningFunding Source: NIH/NHBLIRole: Research AssociateThis goal of this study is to elucidate the biological function of anticoagulant heparan sulfate (HSAT+) in cardiovascular diseases, in particular sepsis/septic shock. From December 2006 to December 2011 (5 years 1 month) Lebanon, NHPh.D. Candidate @ Radboud University Nijmegen Emphysema and Smoking-Related Changes In Heparan SulfatesFunding Source: Radboud University NijmegenRole: Ph.D. CandidateThis study aims to elucidate which structural alterations in heparan sulfate (HS) are involved in the pathogenesis of emphysema, and which alterations are induced by smoking. Project includes selection of scFv anti-HS antibodies using phage display technology and antibody characterization and optimization for therapeutic applications. The diagnostic potential of scFv antibodies as markers for the process of emphysema has been evaluated.This work has been described in my thesis entitled: "Heparan Sulfates in Human Lung, Development of Tools and Relation with Emphysema" and has resulted in a US patent, see below. From August 2001 to September 2006 (5 years 2 months) Nijmegen, the NetherlandsResearch Scientist @ The Geisel School of Medicine at Dartmouth Research scientist specializing in the development and optimization of immunomodulatory antibody therapeutics, such as BiTEs and CARs and their use in cancer immunotherapy. From January 2016 to February 2017 (1 year 2 months) Lebanon, NH


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Extraversion (E), Sensing (S), Feeling (F), Perceiving (P)

Average Tenure

3 year(s), 10 month(s)

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Unlikely

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