• Goal driven pragmatic leader • Creates and innovative and supporting environment • 10 years experience in biopharmaceutical process development and production • 20+ different IMPs brought into preclinical and clinical studies • Development of commercial process for lead product candidate (industrial scale) • Lead multidisciplinary international project teams incl. CMOs of intermediates, drug substance, drug product, contract labs, etc. Core competences: • Biopharmaceutical process development and manufacture • Project leadership • Team leadership • Quality management (GMP) • Regulatory – CMC (reg. requirements, IMPD/IND filings, HA meetings, etc.) • CMO Management

Project Manager New Products and CMC @ Main achievements • Project costing, timing and revenue analysis for portfolio review and project selection process • Evaluation of technology transfer for licensed vaccine to newly acquired site From November 2014 to Present (1 year 2 months) Technical Project Leader @ Main achievements: • Strategic project planning across the departments. • Leading the transition of the CMC unit to be run as a virtual biotech company. • Transfer of process to CMO as redesign for phase 3 clinical production and in-market supply. • Leading an international project team in a matrix organisation. • Development of product towards a 4 year shelf life in prefillable syringes. • Design of a product comparability study and assurance of regulatory acceptance thereof. • Design and control of unit budget and spending’s. From May 2013 to November 2014 (1 year 7 months) SwitzerlandHead Life Science Technologies @ Main achievements: • Member of the executive board. • Establishment of the Life Science Technology department as a key unit for Advens. • Transition of the unit to new management (by Alpiq). • Establishment of new business development source for project acquisition in China. From April 2012 to April 2013 (1 year 1 month) Winterthur Area, SwitzerlandProjektleiter Pharma/Biotech, Business Development Pharma/Biotech @ Main achievements: • Market analysis with focus on business expansion in the emerging markets • Definition of business strategy of unit with support of the mother house • New projects acquired in China and Switzerland. From October 2011 to April 2012 (7 months) Winterthur Area, SwitzerlandHead Process Development and Production @ Main achievements: • Successful delivery of material for proof of concept study for external research collaboration partners. • Process design and manufacturing of complex conjugate vaccines. • Market analysis and preparation of unit for management buy-out. • CMC responsible during due diligence From December 2010 to September 2011 (10 months) Manager Process Development @ Main achievements: • Structuring and education of the members of the unit after company reorganization. From September 2010 to December 2010 (4 months) Technical Project Leader @ Main achievements: • Project planning across all departments • Company representation during scientific advice with regulatory authorities • Technology Transfer to licensee From September 2005 to June 2009 (3 years 10 months) Group Leader @ Main achievements: • Bringing > 10 product candidates (VLP based products) into clinical and clinical trials (process development and production) • GMP production of > 20 batches • Creation of an excellent working environment for the group, leading to an outstanding group performance • Co-authoring of > 20 clinical trial applications • Reliable and high quality sourcing of critical raw materials (haptens, peptides, oligonucleotides) From June 2003 to June 2009 (6 years 1 month) Engineer @ Main achievements: • Hands-on production of the first clinical GMP batches of Cytos ImmunodrugsTM. From June 2002 to June 2003 (1 year 1 month)

CAS, General Management @ Universität Zürich From 2008 to 2008 Chemiker FH, Chemie @ Zürcher Hochschule Winterthur From 1997 to 2001 Berufsmatura, Technisch @ Berufsmaturitätsschule Zürich From 1996 to 1997 Laborant, Organische Chemie @ Eidgenössische Technische Hochschule Zürich From 1993 to 1996 Matthias Kinzler is skilled in: Biotechnology, Technology Transfer, GMP, Biopharmaceuticals, Leadership, Pharmaceutical Industry, CMC, Process Engineering, Lifesciences, R&D, Drug Development, FDA, Comparability, Biotechnologie, Technologietransfer