Phase-I CNS Pharmacodynamics/PD and Pain investigations: Laser Pain Model (Laser evoked potentials LEPs, at normal, UV- and capsaicin skin), mechano-sensory evoked potentials, psychophysics, vigilance, cognitive and psychomotor research (EOG, CRT, AEP, VEP etc.) Checks for onset, time- and dose-efficacy, combinations, interactions (e.g. parenteral alcohol interaction model), normobaric hypoxia model in healthy volunteers (with evoked potentials, eye movements, pursuit tracking, ERG etc.) Active in contracting research since 1976, principal investigator in > 150 studies Publications and presentations > 175 Specialties: Pharmacodynamics of CNS Electrophysiology in Humans Pain Research in Humans Development of Models and methods (PoC) Bioengineering

Managing and Medical Director (CEO) @ Design and Development of Human Methodology and Modeling in Phase-I CNS pharmacodynamics (hard- and software) and conduct of experimental CNS and pain studies (PoC) New address since Oct. 2010 (but old phone, fax and e-mail): HPR Dr. Schaffler GmbH Heisenbergbogen 1, Quadrum D-85609 Aschheim-Dornach / Munich, Germany Phone 0049-89-99322–0 Fax 0049-89-99322-299 E-Mail HPR.Pharmacodynamics@t-online.de Homepage: www.hpr-cro.com From August 2010 to Present (5 years 5 months) Research Professor @ Research professorship at SoP - especially in pain research (working with graduates and post-docs) - to improve Laser and mechano sensory evoked potential technique From April 2008 to June 2012 (4 years 3 months) Managing and Medical Director @ Design and Development of Human Methodology and Modeling in Phase-I CNS pharmacodynamics and (experimental human) pain research (PoC) From June 1999 to July 2010 (11 years 2 months) Head @ phase-I pd unit, vigilance and psycho motor research, drug-alcohol interactions, normobaric hypoxia, quantitative-objective pain (EP) measurements, pk/pd From September 1976 to September 1999 (23 years 1 month) Deputy manager (assistant head) @ Deputy manager of the biomedical engineering department in the Equipment Division at Messerschmitt-Bölkow-Blohm, Ottobrunn / Munich (MBB, later Deutsche Aerospace AG / DASA Daimler Chrysler Aerospace AG, now EADS AG); thereafter consultant for biomedical matters at MBB Applied Technology GmbH, Ottobrunn / Munich for 3 years From 1974 to 1979 (5 years) Scientific staff member @ Scientific staff member at the Institute for Industrial Physiology of Munich Technical University (Prof. Dr. med. W. Müller-Limmroth) Department of Psychophysiology and Ergonomics From 1973 to 1974 (1 year) Scientific staff member (Captain) @ Scientific staff member and captain in the medical corps at the Institute of Aviation Medicine of the German Air Force in Fürstenfeldbruck/Munich, IIIrd Department: experimental aerophysiology (team for neuro-sensory physiology) From January 1972 to December 1973 (2 years)

MD, Medicine @ Technical University Munich From 1965 to 1971 Klaus Schaffler Dr., MD is skilled in: Clinical Research, Clinical Development, Drug Development, Neuroscience, Clinical Pharmacology, Pain Management, Medical Writing, Science, Oncology, CRO, GCP, Drug Discovery