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Christian Dombrowski

Director

Senior Director - Protein Engineering and Production at Intellia Therapeutics, Inc.

Boston, Massachusetts

Section title

Christian Dombrowski's Email Addresses & Phone Numbers

Christian Dombrowski's Work Experience

Acustem Pte Ltd

Director

June 2010 to July 2012

Intellia Therapeutics, Inc.

Senior Director - Protein Engineering and Production

Cambridge, MA

Intellia Therapeutics, Inc.

Associate Director - Head of Molecular Biology group

February 2015 to December 2017

Cambridge, MA

Christian Dombrowski's Education

Universite Laval

Ph.D., Molecular and Cell Biology

1999 to 2003

Universite Laval

M. Sc., Molecular Genetics

1997 to 1999

Universite Laval

B. Sc., Biochemistry

1994 to 1997

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Christian Dombrowski's Estimated Salary Range

About Christian Dombrowski's Current Company

Acustem Pte Ltd

Frequently Asked Questions about Christian Dombrowski

What company does Christian Dombrowski work for?

Christian Dombrowski works for Acustem Pte Ltd


What is Christian Dombrowski's role at Acustem Pte Ltd?

Christian Dombrowski is Director


What is Christian Dombrowski's personal email address?

Christian Dombrowski's personal email addresses are c****[email protected], and c****[email protected]


What is Christian Dombrowski's business email address?

Christian Dombrowski's business email addresses are not available


What is Christian Dombrowski's Phone Number?

Christian Dombrowski's phone (413) ***-*274


What industry does Christian Dombrowski work in?

Christian Dombrowski works in the Pharmaceuticals industry.


Who are Christian Dombrowski's colleagues?

Christian Dombrowski's colleagues are Simo Arredouani, Jose Rivera, Kylie McNamara, John Leonard, Moitri Roy, Jonathan Finn, Dandan Ling, Walter Strapps, Michael PhD, and Deep Goyal


About Christian Dombrowski

📖 Summary

Director @ Acustem Pte Ltd From June 2010 to July 2012 (2 years 2 months) Senior Director - Protein Engineering and Production @ Intellia Therapeutics, Inc. Cambridge, MAAssociate Director - Head of Molecular Biology group @ Intellia Therapeutics, Inc. From February 2015 to December 2017 (2 years 11 months) Cambridge, MAResearch Fellow @ Institute of Molecular and Cell Biology • Established an original method to enhance the proliferation of human mesenchymal stem cells for their optimal in vitro expansion, thus obtaining the therapeutic numbers of cells required for in vivo injections. From January 2004 to January 2008 (4 years 1 month) Post-doctoral Position @ Human and Molecular Genetic Research Unit • Sought to create a diagnostic test for Fragile-X syndrome patients. Using specific monoclonal antibodies that I produced during my Ph.D., I prepared an ELISA assay to quantify the Fragile-X Mental Retardation protein (FMRP) in the plasma of healthy and affected patients. From January 2003 to December 2003 (1 year) Senior Scientist-Cell based assay development @ Eleven Biotherapeutics Scientist II - August 2011 - April 2013As a project leader I developed several technologies and platforms to improve drug-like properties of biologics and accelerate development of new candidates • A platform for the ocular surface retention of biologics that resulted in a significant increase in residence time and dramatically increased the potency of fused biologics • A yeast display platform for immunoprediction using HLA display and peptide libraries • Adapted our proprietary yeast display platform for thermostability engineering by directed evolution• Optimized lentiviral delivery for the rapid establishment of highly productive mammalian cell lines (up to 300mg/L) for research proteins• Cell based assay development for the screening of drug candidates in a collaboration with Thrombogenics From August 2011 to February 2015 (3 years 7 months) Research Scientist-Project Leader @ DDR Diabetes, Lilly Singapore Center As a project leader, I supervised a team focusing on the development of assays in primary cells to identify novel target for the treatment of type 2 diabetes• Modified lentiviral coating proteins for the targeting of primary hepatocytes • Optimized an infection protocol resulting in >90% infection efficiency of cell lines and primary cells• Supervised the establishment of multiple functional cell-based assays using primary hepatocytes, myotubes and stem cells differentiated into adipocytes• Screened over 800 shRNA targeting 200 epigenetic genes and identified 4 novel targets for the treatment of diabetes type 2• Coordinated the biological activities in a collaborative venture with a consortium comprising academic institutions across Singapore and New Zealand From January 2009 to December 2010 (2 years) Senior Research Fellow @ Institute of Medical Biology As a postdoctoral fellow I invented a method for the rapid purification of growth factor-specific carbohydrates and most importantly, BMP2-specific heparan sulfates which demonstrated therapeutic efficacy in a non-union fracture model in rabbits. I deciphered key steps in the FGFR1 signaling pathway leading to multipotent human mesenchymal stem cell proliferation. From February 2008 to January 2009 (1 year) Institute of Medical Biology, SingaporeDirector - Protein Engineering and Production @ Intellia Therapeutics, Inc. From January 2018 to November 2018 (11 months) Cambridge, USA


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In a nutshell

Christian Dombrowski's Personality Type

Extraversion (E), Sensing (S), Feeling (F), Judging (J)

Average Tenure

2 year(s), 2 month(s)

Christian Dombrowski's Willingness to Change Jobs

Unlikely

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