Isaac Ho's Email Addresses & Phone Numbers

Senior software engineer / budding iOS developer on the lookout for interesting part-time work. I have a useful blend of algorithmic agility and professional implementation chops, backed by experience across a wide spectrum of project types. I am solid in Java, C, C++, OO design fundamentals and industry best practices. I have a track record of being...

Senior software engineer / budding iOS developer on the lookout for interesting part-time work. I have a useful blend of algorithmic agility and professional implementation chops, backed by experience across a wide spectrum of project types. I am solid in Java, C, C++, OO design fundamentals and industry best practices. I have a track record of being effective in new domains quickly and am easy to work with. Areas of focus include: ● bioinformatics ● R&D ● optimization ● multithreading/multiprocessing ● advanced data structure/algorithm design ● Java visualization ● iOS/Swift I have completed an 8-week intensive iOS/Swift bootcamp at Codepath. Our team's app for facilitating live-event nonprofit donations for SamaHope won an Honorable Mention in Codepath's Bay Area-wide competition and was rated top 6 out of 30+ contenders by industry experts.Senior Software Engineer / Bioinformatics (part-time) @ Lead engineer on 3-man team for Meraculous, a short-read genome assembler that handles gigabase-scale genomes on high­ performance clusters using a deBruijn graph approach. In the Assemblathon 2, Meraculous was peer-reviewed to be top 3 in the field for accuracy, while being significantly faster, more memory-efficient and scalable than other leading assemblers. ● Extended the Landau-Vishkin read alignment algorithm to support local alignment and a mismatch penalty while maintaining big-O runtime bound ● Designed and implemented a multithreading model for the core modules of Meraculous, using 65k google:sparse_hashes and spinlocks designated by DNA prefix to balance memory footprint and efficiency ● Rewrote core modules in C++, using efficient binary-to-text conversion, custom DNA sequence class, and careful profiling to achieve >5x throughput over existing Perl version ● Developed novel lightweight hash data structure for k­mer lookups that does not need to store the keys themselves, storing the entire assembly k­mer graph in approximately 4 bytes per genomic base ( an improvement of ~100x over competing approaches ) ● Developed a machine learning / random ­forest prototype in WEKA to improve k­mer extension accuracy of contigs, producing a 90% reduction in error-rate From 2006 to Present (9 years) Java Engineer / Independent Contractor (part-time) @ Bioniks had a MATLAB prototype that enhanced the tracking of skeletal markers provided by a single Microsoft Kinect for use in orthopedic evaluations; it was shown to provide comparable quality to industry-standard camera systems costing >$100K. However, it was very slow ( ~1fpm ) and lacked any kind of interface. Using this code as a starting point, with no previous domain knowledge and as sole engineer, I successfully designed and built a real-time 24fps Java interface using OpenCV/OpenNI to track key metrics like knee flexion and hip drop. The project milestone was reached in just 80 hours, 50% under budget. From June 2012 to September 2012 (4 months) Software Engineer / Independent Contractor (part-time) @ Developed the GO-Elite plugin for Cytoscape, providing researchers with an integrated way to mine gene expression data using overrepresentation analysis. ● Integration involved manipulation of core Cytoscape data structures, implementation of an OPAL webservice client, and using threading to boost the Swing GUI performance ● Implemented RESTful webservice for BridgeDb, providing easy and robust programmatic id­mapping across various standard biological id systems From September 2008 to March 2012 (3 years 7 months) Software Engineer @ ● Lead engineer on 5-man team for developing overlap-layout-consensus assembly tools for Sanger data, converting prototype code to industry-grade C++ code with unit tests and best practices ● Built structural variant analysis tool in Perl to bulk-detect insertions/deletions/transversions in Arabidopsis paired-end reads in support of original research ● Core developer for JAZZ Sanger-read assembler From September 2001 to 2005 (4 years) Software Engineer @ ● Built an automated settlement engine, which interfaced web transactions with Great Plains accounting software to print checks and invoices to venues/promoters automatically each week ● Developed an e­-commerce prototype, a JSP/EJB web space for reserving tour tickets to the White House ● Enhanced and maintained core website written in C, an e­-commerce ticketing front­end with a web-­based back end allowing venues and promoters full control over their events From 1999 to 2001 (2 years) Lecturer @ Lecturer for: Data Structures with Java, Discrete Math, and Formal Methods ● Prepared lecture materials, designed exams, led tutorials, gave lectures in hall of 600+ students ● Supervised student software projects ● Facilitated extra-curricular workshop on game programming in C++ From 1998 to 1999 (1 year) Bachelor's Degree, Computer Science with Honors @ Princeton University From 1994 to 1998 iOS development in Swift @ Codepathstrack intermediatestrack intermediate Isaac Ho is skilled in: Lifesciences, Bioinformatics, Biotechnology, Training, Data Analysis, Computational Biology, Molecular Biology, Algorithms