Professor at MD Anderson Cancer Center
Washington University in St. Louis
Doctor of Medicine (MD)
1984 to 1986
The University of North Dakota
Doctor of Philosophy (Ph.D.) Anatomy
1977 to 1982
University of California, San Diego
Bachelor of Arts (BA) Biology/Biological Sciences General
1975 to 1977
United States International University
Associate of Arts (AA) Biology General
1971 to 1975
What company does Timothy McDonnell, MD, PhD work for?
Timothy McDonnell, MD, PhD works for MD Anderson Cancer Center
What is Timothy McDonnell, MD, PhD's role at MD Anderson Cancer Center?
Timothy McDonnell, MD, PhD is Professor and Deputy Chair, Department of Hematopathology
What industry does Timothy McDonnell, MD, PhD work in?
Timothy McDonnell, MD, PhD works in the Hospital & Health Care industry.
I have been a practicing physician scientist for over 20 years. My clinical activities are in the area of diagnostic hematopathology. My research program is devoted to mechanistic studies focused on clinically relevant issues in cancer biology, for example, molecular mechanisms of therapeutic resistance. A variety of approaches are employed varying from histopathology to molecular biology. Our research involves the use of patient material as well as established cell lines and genetically engineered strains of mice, some of which we generate in our laboratory. During fellowship training in Dr. Stan Korsmeyer’s laboratory we demonstrated the oncogenic potential of bcl-2 in a transgenic mouse model recapitulating the t(14;18) translocation that occurs at high frequency in follicular lymphoma. Interestingly, we were among the first groups to demonstrate the importance of bcl-2 as a regulator of apoptotic cell death. Until joining the Department of Hematopathology, as Deputy Chair, several years ago much of my research effort was devoted to studies of solid tumors, including cancers of the prostate and skin. Since joining with the Department of Hematopathology my research focus has been reoriented to the study of hematolymphoid malignancies and the role of signaling events commonly altered in lymphoid malignancies such as those mediated by the sonic hedgehog and p53 signaling axes. Further, we have devoted considerable effort to developing and adapting methodologies to undertake genome-wide assessments from human tumor samples, including archived formalin-fixed paraffin-embedded tissue. The ultimate goal of these studies is to enable rational stratification of patients with cancer and develop effective, mechanism-based therapies.Professor and Deputy Chair, Department of Hematopathology @ From 2007 to Present (8 years) Doctor of Medicine (MD) @ Washington University in St. Louis From 1984 to 1986 Doctor of Philosophy (Ph.D.), Anatomy @ The University of North Dakota From 1977 to 1982 Bachelor of Arts (BA), Biology/Biological Sciences, General @ University of California, San Diego From 1975 to 1977 Associate of Arts (AA), Biology, General @ United States International University From 1971 to 1975 Timothy McDonnell, MD, PhD is skilled in: Molecular Biology, Pathology, Cancer, Medical Education, Research, Clinical Research, Laboratory, Cell Biology, Lifesciences, Biotechnology, Western Blotting, Oncology, Translational Research, Science, Hematopathology
Introversion (I), Intuition (N), Feeling (F), Perceiving (P)
8 year(s), 0 month(s)
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