Vice President, Immunology @ Elstar Therapeutics Inc.
Senior Director, Head of Immunology @ FORMA Therapeutics, Inc.
Director, Head of Cellular and Translational Immunology @ EMD Serono Research & Development Institute
16 years of biopharmaceutical industry experience in drug discovery and development. Research interests spanning small- and large-molecule therapeutics, novel protein modalities and their therapeutic applications in immunology and oncology, interconnected through a common interest in approaches aiming at modulating the immune response. Department head capable of supervising cross-functional groups in target identification and validation, lead discovery, and
16 years of biopharmaceutical industry experience in drug discovery and development. Research interests spanning small- and large-molecule therapeutics, novel protein modalities and their therapeutic applications in immunology and oncology, interconnected through a common interest in approaches aiming at modulating the immune response. Department head capable of supervising cross-functional groups in target identification and validation, lead discovery, and translational research and development efforts. Well versed in different aspects of development and implementation of drug hunting, including high throughput biochemical and cell-based assays, lead selection, lead optimization, pharmacologic evaluation of compounds, identification of biomarkers and patient stratification strategies. Demonstrated ability to deliver project milestones and mentor junior project leaders and scientists. Responsible for setting goals, career development and performance appraisals. Visible and well-connected in the immunology and oncology research community; over 60 publications and book chapters.
Specialties: Autoimmune Disease, Inflammation, Oncology, Antiviral, Small-molecule Therapeutics, Bispecific Antibodies, Antibody Drug Conjugates, Cell-penetrating Peptide Therapeutics, Protein-protein Interactions
Senior Director, Immunology @ From June 2015 to Present (7 months) Greater Boston AreaDirector, Head of Cellular and Translational Immunology @ Develop cellular assays using primary human cells derived from healthy donors and patient cohorts to support the discovery of NCE and NBE as well as their non-clinical evaluation
Advance mechanistic understanding and thus proof of confidence of novel therapeutic agents for autoimmune disease
Provide scientific hypotheses, technologies and experimental data needed for translation of disease-relevant biomarkers monitored in vitro to in vivo disease models
Establish external collaborations with key experts/technologies and to drive academic, clinical research collaborations From May 2013 to May 2015 (2 years 1 month) Interim Consultant @ Advise clients in the biopharma industry on early research and development projects
Liaise with CROs in implementation and execution of such projects
Preparation and presentation of scientific data to KOLs and SABs following clients' requests From February 2013 to June 2013 (5 months) Research Leader/Associate Director @ Utilize and build extensive immunology expertise to help identify and validate drug targets for autoimmune disorders including rheumatoid arthritis, systemic lupus erythematosis and inflammatory bowel disease
Effectively direct research efforts to accelerate decision making and facilitate the preclinical development of drug candidates.
Design and implement pharmacodynamic models based on appropriate immunopharmacology and mechanism of action to establish PK/PD/ and preclinical efficacy model relationships to enable human dose selection.
Interface with Discovery, Translational Research and Early Clinical Development teams to develop an end-to-end strategy as well as personalized health care/biomarker approach to drug development in order to enable a rapid transition of small molecules and biologics from lead optimization through clinical candidacy into early clinical trials.
Serve as a project leader to lead key developmental activities in a project team setting before and/or after the identification of a clinical candidate.
Establish effective networks with internal and external stakeholders, and between different functional and/or therapeutic areas
Maintain a scientific presence related to inflammation/autoimmunity within the internal and external scientific community through collaborative scientific interaction and publication in peer reviewed scientific journals
Identify and help prioritize licensing opportunities
Manage and progress external alliances From October 2010 to February 2013 (2 years 5 months) Principal Scientist @ Utilize and build innate immune signaling expertise to help identify and validate drug targets for cancer indications From September 2006 to October 2010 (4 years 2 months) Senior Research Scientist @ Utilize and build immunology expertise to help identify and validate drug targets for infectious diseases and autoimmune disorders From September 2003 to September 2006 (3 years 1 month) Adjunct Assistant Professor @ PhD advisory committee member and guest lecturer / seminar speaker From May 2001 to May 2005 (4 years 1 month) Research Scientist @ From September 2000 to August 2003 (3 years)
Ph.D., Microbiology @ University of Washington School of Medicine From 1994 to 1999 Mini-MBA, Biopharmaceutical Innovation @ Rutgers University Center for Management Development From 2011 to 2011 B.S., Biotechnology, Microbiology @ Minnesota State University, Mankato From 1990 to 1994 Seng-Lai Ph.D. is skilled in: Drug Discovery, Drug Development, Immunology, Assay Development, Biomarkers, Clinical Development, Pharmacology, Oncology, Translational Research, Biopharmaceuticals, Clinical Trials, Genomics, Antibodies, CRO, Inflammation
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