Scientific Advisor to The Editors @ Journal of Pharmaceutical Sciences
Assistant/Tenured Associate Professor & Director-Cellular Engineering & Nano-Therapeutics Lab @ University of Michigan
Graduate Teaching & Research Assistant @
University of Mississippi
I am a Pharmaceutics, Drug Delivery, and Product Development scientist with +20 years of experience in academia and pharmaceutical industry. My career goal is to develop innovative platform technologies to address formulation problems of small molecules and biologics to enable their development into commercially viable pharmaceutical products. I have 3 published patent applications, 40 manuscripts, +110 conference
I am a Pharmaceutics, Drug Delivery, and Product Development scientist with +20 years of experience in academia and pharmaceutical industry. My career goal is to develop innovative platform technologies to address formulation problems of small molecules and biologics to enable their development into commercially viable pharmaceutical products. I have 3 published patent applications, 40 manuscripts, +110 conference proceedings, and delivered +50 invited talks. My research has been recognized by multiple national awards including the 2013 Young Investigator Award (Frontiers in Bioengineering Workshop, Parker H. Petit Institute for Bioengineering & Bioscience), Coulter Foundation Translational Research Partnership Award (2008-2010), NSF CAREER Award (2008), US DOD Breast Cancer Research Award (2005-2008), Komen Foundation Award (2005-2008), and National Cancer Center Fellowship (2004-2005).
As the Director of a multidisciplinary team, I promote increased understanding across multiple functional areas, constantly mentor junior scientists, focus on developing clear plans, and create an environment that supports success. My leadership style is collaborative and purposeful and I hold team members accountable for their roles. I’m proficient in forecast/development of complex budgets for large multidisciplinary projects. I currently lead a team of 3 Ph.D. and 7 MS scientists assembled into project teams focusing on the development of innovative formulations of therapeutic and imaging agents for detection and treatment of cancer.
* Development of oral and parenteral formulations
* Synthesis of 2nd generation Antibody-Drug Conjugates (ADCs)
* Development of DNA/RNA formulations
* Formulation of nano-bubbles for ultrasound imaging/therapy
* In vitro models of the blood-brain barrier
* Selection/evaluation of oral bioavailability enhancers
* Assembly and leadership of cross-functional teams
* Project management and implementation
* Coaching of junior scientists
Visiting Research Scientist, Drug product Development @ Joined the Pharmaceutics/Formulation group at AbbVie Inc. to provide technical support for multiple initiatives aiming to address formulation challenges for NCE and NBE. These initiatives include:
• Establishing biopolymer synthesis capacity in the pharmaceutics/formulation group to enable the development of customized formulations (e.g. liposomes, micelles, nanoparticles, polymer-drug conjugates, hydrogels) to overcome challenging physical and chemical properties (e.g. poor solubility, low permeability, enzymatic instability) and enable assessment of activity.
• Provide leadership for four separate projects focusing on development of platform technologies for: i) selective delivery of NCEs to cancer cells in cellular assays and tumor models
ii) targeted delivery of small molecules and biologics to the GIT in IBD models
iii) enhancing oral permeability of small molecules and biologics
iv) addressing physical/chemical instability of antibody-drug conjugates (ADCs)
• Technical training of junior scientists on novel formulation approaches for NCEs and NBEs. From February 2015 to Present (11 months) Director, Cellular Engineering & Nano-Therapeutics Laboratory (CENT LAB) @ As a Tenured Associate Professor and the Director of the Cellular Engineering & Nano-Therapeutics Laboratory (www.bme.umich.edu/centlab.php), my research program encompasses two parallel research tracks. Track I focuses on formulation of challenging small molecules, biologics (DNA, RNA, peptides, and proteins), and ultrasound contrast agents into effective oral/parenteral therapies. Track II is focused on biopharmaceutics with special interest in design/evaluation of new “enhancers” to increase the solubility, permeability, and oral bioavailability of NCE and NBE. We also established a physiologically-relevant in vitro model of the blood-brain barrier (BBB) to assess the permeability of NCE/NBE and delivery strategies into the brain. Ongoing research projects are established on a strong scientific foundation with the ultimate goal of developing commercially-viable products that address critical unmet medical needs. Ongoing research projects have been supported by grants from federal agencies (NSF, DOD, NIH) and private foundations (Coulter, Komen, NCC) totaling +$4,500,000. Since January 2007, I have mentored/coached 15 Ph.D., 7 MS, and 18 BS scientists in the group. I currently lead a research team of 3 Ph.D. and 7 MS scientists assembled into multiple project teams. From January 2007 to Present (9 years) Senior Research Fellow @ • Synthesized pH-sensitive polymer-peptide conjugates for condensation of therapeutic silencing RNA into "smart" particles and characterized the physical/chemical properties of the formulations.
• Investigated particles stability, activity, and toxicity using a range of cell-based assays.
• Investigated the ADMET of 14C-/3H-labeled formulations in small animal models.
• Mentored a team of 2 Ph.D. and 6 MS scientists working on multiple research projects focusing on drug delivery and tissues engineering using polymeric constructs.
• Principal Investigator on three fellowships/grants from the National Cancer Center, US Department of Defense, and Susan G. Komen Breast Cancer Foundation supporting the development of novel formulations for targeted delivery of silencing RNA for breast cancer therapy.
• Lectured on drug delivery, PK/PD, and polymer therapeutics to graduate students in the bioengineering program. From November 2002 to August 2006 (3 years 10 months) Technical Consultant @ • Consulted on the setup of the In Vitro Bioassays Lab (aseptic cell culture, screening of permeability of NCE, dissolution and solubility studies, etc.).
• Consulted on the formulation strategy of a therapeutic peptide using FDA-approved polymers for parenteral administration and the associated stability and efficacy studies. From May 2004 to April 2005 (1 year) Graduate Student Research Assistant @ • Synthesized fluorescently-labeled polymers, characterized the products using gel permeation chromatography, UV/VIS and fluorescence spectroscopy.
• Investigated the permeability of fluorescently-labeled polymers across Caco-2 and MDCK cell monolayers; Developed HPLC methods for analysis of solutes.
• Reported the results of my research in regular weekly reports, group meetings, conference proceedings, and research manuscripts.
• Instructor of the Pharmacy Practice Lab taught to P3 students in the professional pharmacy program. From August 1999 to August 2002 (3 years 1 month) Research Scientist @ • Screened the solubility and permeability of NCE across Caco-2 and MDCK cell monolayers; Developed HPLC methods for solutes analysis.
• Transferred an in vitro model of the blood-brain barrier from a CRO and established it in-house to support permeability screening of NCE.
• Reported/presented the results of my research in regular weekly reports, group meetings, conference proceedings, and research manuscripts. From June 2000 to July 2002 (2 years 2 months) Baltimore, Maryland AreaVisiting Research Scientist, Circulatory Research Laboratory @ • Investigated the diffusion of FITC-labeled polymers across vascular networks in the cremaster muscle of guinea pigs using intravital microscopy techniques.
• Processed digital images of vascular networks and calculated fluorescence intensity in different regions of interest (ROIs) to calculate particle's diffusion rates. From August 1998 to August 1999 (1 year 1 month) Graduate Student Research Assistant, Department of Pharmaceutics @ • Enrolled in pharmaceutics MS program; finished graduate courses for MS & Ph.D. degrees.
• Instructor for Pharmaceutical Dosage Forms Lab for P1/P2 students in the professional pharmacy program.
• Graduate Research Assistant in the National Center for Natural Products Research.
• Taught pharmaceutics and industrial pharmacy labs for undergraduate pharmacy students. From August 1997 to July 1999 (2 years) Research & Teaching Assistant @ • Analytical method development, formulation, and characterization for topical and oral dosage forms for CROs.
• Taught pharmaceutics and industrial pharmacy labs for students in the professional pharmacy program. From October 1994 to May 1996 (1 year 8 months) Summer Intern, Quality Control Division @ • Analysis (UV/VIS, HPLC, TGA) of raw API and finished pharmaceutical products (liquid and solid dosage forms, creams, and ointments) following USP protocols. From May 1993 to August 1993 (4 months)
Doctor of Philosophy (Ph.D.), Pharmaceutical Sciences (Drug Delivery, Metabolism, and Pharmacokinetics Track), 4.0/4.0 @ University of Maryland, Baltimore (UMB) From 1999 to 2002 Graduate Teaching & Research Assistant, Pharmaceutics, 3.8/4.0 @ University of Mississippi From 1997 to 1999 Bachelor's Degree, Pharmacy, Cumulative Grade: Very Good @ Cairo University From 1989 to 1994 Mohamed Ph.D. is skilled in: Pharmaceutical Industry, Cell Culture, Drug Delivery, Science, HPLC, Cell, Molecular Biology, Formulation, Polymer Chemistry, Gene Delivery, Pharmaceutical Formulations, Nanotechnology, Life Sciences, Research, UV/Vis
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