A dynamic, results driven, professional with 20 years’ experience in a number of roles in Alliance and Distributor management, commercial development, clinical project leadership, Business Development & R&D A strong track record in strategic, operational and transactional activities closely aligned with well developed interpersonal and networking skills and a proven ability to manage multiple complex projects, across functional and territorial boundaries at all levels of management. I recently moved to Clinigen as Head of Business & Commercial Development. Previously I was responsible for managing BTGs expanding portfolio of distribution partners across all business units. I lead one of BTGs critical care franchises, DigiFab and managed and developed our specialty pharmaceutical distribution partners. I was also franchise leader for BTGs multiple sclerosis program, when it was in Phase II studies Previously, Senior Business Development Exec at BTG with responsibilities for in and out-licensing activities in multiple therapeutic areas especially oncology and CNS.

Head of Business & Commercial Development @ Overall responsibility for identifying and developing business and commercial growth opportunities for the Global Access business at Clinigen From November 2015 to Present (2 months) Director, Alliances & Distribution @ Lead & co-ordinate BTGs global distribution network across all of our business units, providing a range of services, including technical support, strategic advice, coordination of contract management & forecast delivery. Leading the team to identify and contract with high quality partners Work closely with regional business leaders and General Managers across all business units Lead new market entry and geographic expansion strategy development & execution Ensuring deals are negotiated in the best interests of BTG and partners are actively managed. Responsible for maintaining a compliant network, on boarding new partners and managing the exit of underperforming ones Key player in the development and execution of a large “go direct” project across Europe and Latin America From October 2013 to October 2015 (2 years 1 month) London, United KingdomFranchise Leader & Spec Pharma Alliance Manager @ Franchise Leader role: Provide overall accountability, leadership and general management expertise to a key critcal care product. Ensuring that the company and project team is developing the right drug, in the right way, for the right market opportunity Constantly ensuring that product strategy is aimed at creating value for the company and fits with the company’s goals and objectives as well as its Vision and Values. Strategic Alliance Manager role: Provide key strategic leadership of the BTG Speciality Pharmaceuticals trade / sales activities. Develop and maintain key relationships with distribution partners and sales channels Lead the value proposition and pricing strategy for key products in the portfolio From December 2011 to October 2013 (1 year 11 months) London, United KingdomSenior Business Development Executive @ Franchise Leader for Pleneva Phase II MS program From 2005 to June 2011 (6 years) Business Development Manager @ From 2001 to 2005 (4 years) Business Development Manager @ From 2001 to 2005 (4 years) Research Scientist @ From 1997 to 2001 (4 years) Clinical Scientific Officer @ From 1995 to 1997 (2 years)

Management @ The Open University From 2002 to 2003 BSc (Hons), Microbiology, General @ Liverpool John Moores University From 1991 to 1995 Lee Holmes is skilled in: Global Channel Management, Global Alliance Management, Geographic Expansion, Business Development, Pharmaceutical Industry, Management, Business Strategy, Business Alliances, Oncology, Biotechnology, Cross-functional Team Leadership, Negotiation, Building Relationships, Technology Transfer, Lifesciences, Licensing, People Management, Communication