Jeffrey D. Marrazzo is the co-founder and chief executive officer of Spark Therapeutics, Inc. (NASDAQ: ONCE) and serves on the board of directors. Jeff has led the creation and growth of Spark from a research center within The Children's Hospital of Philadelphia to a publicly-traded, integrated gene therapy company developing one-time, life-altering treatments to transform the lives of patients and re-imagine the treatment of debilitating diseases. Under Jeff's leadership, Spark has raised more than $267 million in capital, established a global collaboration with Pfizer for the development and commercialization of a gene therapy for hemophilia B, recruited some of the world's pioneers in gene therapy together with a team of biotechnology industry executives, and advanced the company's lead product candidate for the treatment of rare, blinding conditions to a fully-enrolled Phase 3 clinical trial. Jeff is an experienced entrepreneur dedicated to curing disease through precision medicine, having helped build and sell the first genetic testing benefit management and pharmacogenomics medicines company to CVS Caremark. Previously, Jeff served as an advisor to former Pennsylvania Governor Edward G. Rendell. Jeff received his B.A. in economics, magna cum laude, and B.S.E. in systems science and engineering, magna cum laude, from the University of Pennsylvania, and holds a dual M.B.A. / M.P.A. from The Wharton School and Harvard University, a program which he founded.

Co-Founder, CEO and Director @ First as a consultant to The Children's Hospital of Philadelphia (CHOP) and then as co-founder, CEO and director of Spark Therapeutics, Inc., Jeff has led the creation and growth of Spark from a research center within CHOP to a publicly-traded, integrated gene therapy company developing one-time, life-altering treatments to transform the lives of patients and re-imagine the treatment of debilitating diseases. From January 2011 to Present (4 years 10 months) Greater Philadelphia AreaSenior Vice President, Corporate Strategy and Business Development @ Part of the founding management team and SVP of corporate strategy and business development of the first genetic testing benefit management and pharmacogenomics medicines company, up to and following the acquisition of a majority of the company’s shares by CVS Caremark. From October 2008 to December 2010 (2 years 3 months) Greater New York City AreaSpecial Assistant to Pennsylvania Governor Edward G. Rendell @ Advisor to the 45th Governor of Pennsylvania on issues relating to Medicaid, long-term living, government management and productivity, the National Guard, emergency management and the gaming industry. From June 2003 to June 2007 (4 years 1 month) Harrisburg, Pennsylvania Area

Master of Business Administration (MBA), Health Care Management @ University of Pennsylvania - The Wharton SchoolMaster of Public Administration (MPA) @ Harvard UniversityBachelor of Science in Engineering, Systems Science and Engineering @ University of PennsylvaniaBachelor of Arts, Economics @ University of Pennsylvania