Postdoctoral Research Assistant @ Targeting Discovery Institute, Nuffied Department of Medicine
Postdoctoral Researcher @ The Weatherall Institute of Molecular Medicine
PostDoc @ Cancer Research UK
List of publications in NCBI
Postdoctoral Research Assistant @ High throughput screening facility at the TDI is to provide research scientists with access to a comprehensive, cost-effective facility capable of running high throughput cell based small compound. RNAi and CRISPR screens as well as biochemical small compound screens From September 2015 to Present (4 months) Oxford, United
List of publications in NCBI
Postdoctoral Research Assistant @ High throughput screening facility at the TDI is to provide research scientists with access to a comprehensive, cost-effective facility capable of running high throughput cell based small compound. RNAi and CRISPR screens as well as biochemical small compound screens From September 2015 to Present (4 months) Oxford, United KingdomPostdoctoral Researcher @ The main aim of this scientific position is to validate a number of targets within the field of lipid metabolism sufficiently that they will be considered for initiation of a drug discovery effort.
Specifically the programme has the following objectives:
1. To validate that knockdown of the pre-identified target genes causes cell death or growth arrest in breast and prostate cancer cells and human endothelial cells.
2. To further validate that knockdown of target genes prevents growth in 3D cell models.
3. To further validate that knockdown of the selected targets in vivo prevents tumour growth.
4. To define synthetic lethal and combination approaches for lipid metabolism targets.
5. To develop assays for tracking the efficacy of lipid metabolism modulation utilising drugs to pathways and targets known to affect lipid metabolism From October 2011 to September 2015 (4 years) PostDoc @ From 2012 to 2013 (1 year) PostDoc research fellow @ Presently in the process of applying for patents for potential angiogenesis genes. This is part of a project where I have developed laser capture microscopy method to isolate RNA from vessels in breast cancer tissue for gene expression analysis to identify potential anti-angiogenic therapy and angiogenic biomarkers.
In association with these discoveries, my work was key to setting up collaboration with Professor Adrian Harris, University of Oxford and Dr Catherine Kirn-Safran, University of Delaware. In addition I manage multiple research projects, that involves microscope imaging, in-vivo mouse models and standard molecular and cell biology. Essential to this was my successful grant application for Breast Cancer Campaign project grant in 2008, which secured 3 years of funds for continued research.
Additionally I have reviewed several grant applications and scientific papers from a number of international contributors. I have presented important posters featuring my work to industry and academic figures at the Association for Cancer Research, Orlando 2011 and Keystone, Vancouver 2009 and I have both led and contributed to several significant papers.
Other duties include lecturing PhD/MSc students at QMUL, CRUK and I have lectured internationally at University of Tromsø, Norway and University of Coimbra, Portugal. I also regularly undertake Problem based learning facilitator for QMUL medical students. From November 2005 to August 2011 (5 years 10 months) London, United KingdomPostdoctoral research assistant @ Drug development with Cancer Research Technology and Cancer Research UK. High throughput drug screening and identifying mechanism of action of small molecular inhibitors against the hypoxia pathway.
Poster presentations at the American Association for Cancer Research 2004 and National Cancer Research Institute 2005 meetings, and oral presentations at British Cancer Research 2004 and joint CRUK and Institute of Cancer Research 2005 angiogenesis meeting. Additional projects and collaborations set up with The Salk Institute and Malcolm Stevens, Nottingham University. Published papers (see publication). From April 2003 to October 2005 (2 years 7 months) Oxford, United KingdomResearch Assistant @ PhD project with supervisors Dr R.G. Wickremasinghe and Dr. K. Ganeshaguru on survival and programmed cell death (apoptosis) of Chronic Lymphocytic Leukaemia (CLL) and Acute Myeloid Leukaemia (AML).
Additional projects included multidrug resistance phase I clinical trials for Medical Research Council (MRC) and Eli Lilly, following training in Lilly’s Indianapolis facility for multidrug analysis.
Commitments included laboratory supervision of medical students and training new PhD students and medical technical officers for research projects and clinical trials.
Achievements include paper publications (see publications) and several poster presentations at British,
European and American Society of Haematology. From 1997 to 2003 (6 years) Medical Technical Officer @ Researched survival and apoptosis of B-CLL cells and multidrug resistance phase I clinical trials. Presentations at British, European and American Society of Haematology. From 1994 to 1997 (3 years)
PhD, Leukaemia signal transduction @ University College London, U. of London From 1997 to 2002 Dylan Jones is skilled in: Cell Biology, Cancer Research, Cell, Western Blotting, Molecular Biology, Biotechnology, Lifesciences, In Vivo, Cell Culture, Biomarkers, Assay Development
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